Searchable abstracts of presentations at key conferences in endocrinology

ea0011p254 | Diabetes, metabolism and cardiovascular | ECE2006

Liver GH receptor signaling in type I diabetic mice

Wachsman Lital , Eshet Renana , Landau Daniel , Segev Yael

High levels of GH and low levels of IGF-I are found in the serum of type 1 DM. GH binds to its receptor (GHR) and leads to a series of signal transduction reactions, involving phosphorylation of intracellular proteins, including IGF-I and angiotensin II receptor type I (AT1R). It has been previously shown that in type I DM mice there is a decrease in liver GHR levels and circulating IGF-? in spite of increased circulating GH, suggesting a state of GH resistance, although its e...